{"id":12226,"date":"2020-09-17T19:44:10","date_gmt":"2020-09-17T17:44:10","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=12226"},"modified":"2024-11-07T13:50:36","modified_gmt":"2024-11-07T12:50:36","slug":"prof-dr-roman-fedorov","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-roman-fedorov\/","title":{"rendered":"Prof. Dr. Roman Fedorov"},"content":{"rendered":"

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Prof. Dr. Roman Fedorov participates in RESIST research projects D4.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
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The innate immune sensors activate interferon-driven antiviral responses upon recognition of pathogen-associated molecular patterns and serve as a rheostat for the metabolic activity of the microbiota and its exposure to diet, xenobiotics, and infections. The ability to modulate innate immune sensors opens new ways to novel antiviral and anti-inflammatory drugs and therapies against cancer and many aging-associated metabolic, neoplastic, autoimmune, or autoinflammatory disorders. Using unbiased experimental screening combined with computer-aided rational drug design approaches, we aim at developing small-molecule allosteric effectors that specifically enhance or reduce the enzymatic activity of members of the family of innate immune sensors, such as cyclic GMP-AMP synthases (cGAS) and 2′-5′ oligoadenylate synthetases (OAS). To study structural states and conformational changes associated with substrate binding and product release mechanisms of innate immune sensors cGAS and OAS, we apply a combination of three advanced cutting-edge methodologies: time-resolved serial femtosecond crystallography, on-chip substrate or product binding studies, and high-pressure crystallography. The obtained mechanistic information will be used to develop specific allosteric activity modulators of innate immune sensors.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

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<\/i><\/span>Contact<\/span><\/a><\/div>
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Prof. Dr. Fedorov about his scientific work<\/h1><\/div>