{"id":10741,"date":"2020-06-24T19:05:27","date_gmt":"2020-06-24T17:05:27","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=10741"},"modified":"2024-12-18T15:21:22","modified_gmt":"2024-12-18T14:21:22","slug":"prof-dr-beate-sodeik","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-beate-sodeik\/","title":{"rendered":"Prof. Dr. Beate Sodeik"},"content":{"rendered":"

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Prof. Dr. Beate Sodeik participates in\u00a0RESIST research projects A4, D2 and D3.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
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In our research on the cell biology of alphaherpesviruses, we analyse the interactions of viral proteins with host proteins and their relevance for pathogenesis in epithelial cells and fibroblasts of the skin, in immune cells and in neurons. For RESIST, we investigate capsid assembly and early tegumentation of alphaherpesviruses (area D2). In a phenotypic screen, we have identified several small chemical compounds that block assembly of herpes simplex virus (HSV) in the nucleus or the cytoplasm. We now characterize the viral targets of these compounds and evaluate their potential for the development of novel antiviral therapies. The most promising candidates will be validated in primary human keratinocytes and iPSC-derived neurons, and in our recently developed ex vivo<\/i> and in vivo<\/i> murine skin HSV-1 infections models. Furthermore, we support the characterization of the function of potential susceptibility host factors which might contribute to the development of severe HSV and VZV diseases (area A1), and which are identified by the RESIST AD cohort (Atopic dermatitis and disseminated HSV infections) and the Zoster cohort (Severe manifestations of Herpes Zoster).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

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<\/i><\/span>Contact<\/span><\/a><\/div>
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Prof. Sodeik about her scientific work<\/h1><\/div>