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DTSTART;TZID=Europe/Berlin:20260507T130000
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DTSTAMP:20260627T204821
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UID:40345-1778158800-1778162400@www.resist-cluster.de
SUMMARY:RESIST Seminar guest lecture by Luis Schang\, MV\, PhD
DESCRIPTION:Exciting topics\, interestingly presented: Every Thursday\, RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series. \nAttend these exciting seminars of the Cluster of Excellence RESIST\, as a member of RESIST or as a colleague or student. \nOn 7 May 2026 at 1 p.m.\, Luis Schang\, MV\, PhD\, Professor of Chemical Virology\, Department of Microbiology & Immunology\, Baker Institute for Animal Health\, Cornell University\, will give a lecture with the title “HSV-1 and HSV-2 silencing during establishment of latency in human sensory neurons: implications for pathogenesis and therapy”. \nDespite the effective clinical antivirals approved since the 1980’s\, herpes simplex virus 1 and 2 (HSV-1\, -2) continue to pose major and chronic challenges to human health and well-being. Neonatal infections are life-threatening\, ocular infections are the most prevalent infectious cause of corneal transplants in the Western world\, herpes encephalitis is lethal or result in serious sequelae\, and genital herpes increases the risk of HIV infection\, among many other health problems. Herpes simplex viruses are also the cause of major mental health distress and may be involved in Alzheimer’s and other neurodegenerative diseases.\nThe ability of HSV-1 and 2 to establish life-long latent infections in sensory ganglia is the main barrier to effective management because latent virus does not express viral proteins\, which are the targets of most antivirals and vaccines. Latency is challenging to study\, too. We have developed a new model of latency in human sensory DRG and TG-like neurons and wild-type strains or clinical isolates of HSV-1 and -2. Latency is established with no antivirals\, antibodies\, cytokines\, or viral mutants and a low multiplicity\, reflecting the natural human infection. Using this model\, we will show that HSV-1 and -2 lytic genes are expressed during the acute neuronal infection\, viral genomes replicate and PML bodies are destroyed\, while the infection spreads for about 15-23 days before production of infectious virus ceases. Yet\, infected neurons survive\, PMLs reassemble around compacted genomes\, and the viral genomes persist indefinitely into latency. Viral genomes have positioned nucleosomes on day 7\, but nucleosome occupancy and positioning increased in latency. Four nucleosomes were positioned at and around an origin of DNA replication in latency but not during the acute infection. Reactivation up to 56 days after infection induces gene expression\, DNA replication and production of cell-free infectious virus with genomes replicated during the acute infection. Abortive reactivations may occur periodically in exceedingly rare neurons.\nTogether with the number of latent genomes per neuron in cadaveric human samples and latently infected mice\, and the activation of lytic promoters in mice before the establishment of latency\, these results challenge the conclusion that latency is established exclusively by unreplicated viral genomes with no previous lytic gene expression. These findings impact our understanding of the establishment of latency by herpes simplex viruses and the development of new antivirals acting on the critical stages of latency. \nThe lecture will take place in Lecture Hall Q\, Building J06 of the Hannover Medical School. \nIf you are interested in participating via video (online)\, please contact RESIST@mh-hannover.de. \nDo you have any questions or suggestions about the RESIST seminar series? Then please contact us.
URL:https://www.resist-cluster.de/en/veranstaltung/resist-seminar-guest-lecture-luis-schang/
LOCATION:Hannover Medical School\, Building J6\, Lecture Hall Q\, Carl-Neuberg-Str. 1\, Hannover\, 30625
CATEGORIES:seminar (past)
ATTACH;FMTTYPE=image/png:https://www.resist-cluster.de/wp-content/uploads/2026/04/Seminarankuendigung-Schang.png
ORGANIZER;CN="RESIST Cluster of Excellence":MAILTO:RESIST@mh-hannover.de
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DTSTART;TZID=Europe/Berlin:20260521T130000
DTEND;TZID=Europe/Berlin:20260521T140000
DTSTAMP:20260627T204821
CREATED:20260505T072820Z
LAST-MODIFIED:20260522T051918Z
UID:40759-1779368400-1779372000@www.resist-cluster.de
SUMMARY:RESIST Seminar guest lecture by Prof. Dr. Martin Hofmann-Apitius
DESCRIPTION:Exciting topics\, interestingly presented: Every Thursday\, RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series. \nAttend these exciting seminars of the Cluster of Excellence RESIST\, as a member of RESIST or as a colleague or student. \nOn 21 May 2026 at 1 p.m.\, Prof. Dr. Martin Hofmann-Apitius\, Coordinator COMMUTE project & Head of the Department of Bioinformatics at Fraunhofer Institute for Algorithms and Scientific Computing (SCAI)\, will give a lecture with the title “Did the Pandemic increase our risk to develop Alzheimer or Parkinson? The COMMUTE project\, a systematic approach to decipher co-morbidity between infectious and non-infectious diseases”. \nMartin Hofmann-Apitius is working on complex-problem-solving environments for translational biomedicine. The application focus of his computational work is in neurodegeneration and psychiatry; on the computer science side\, he integrates data- and knowledge-based modeling to identify pathophysiology mechanisms suitable for mechanism-based stratification of patient subgroups that can and should be treated based on the underlying disease mechanisms. His most recent project extends that concept towards the reality of co-morbidities. \nThe lecture will take place in Lecture Hall Q\, Building J06 of the Hannover Medical School. \nIf you are interested in participating via video (online)\, please contact RESIST@mh-hannover.de. \nDo you have any questions or suggestions about the RESIST seminar series? Then please contact us.
URL:https://www.resist-cluster.de/en/veranstaltung/resist-seminar-guest-lecture-by-prof-dr-martin-hofmann-apitius/
LOCATION:Hannover Medical School\, Building J6\, Lecture Hall Q\, Carl-Neuberg-Str. 1\, Hannover\, 30625
CATEGORIES:seminar (past)
ATTACH;FMTTYPE=image/png:https://www.resist-cluster.de/wp-content/uploads/2026/05/Seminar_Hofmann-Apitius.png
ORGANIZER;CN="RESIST Cluster of Excellence":MAILTO:RESIST@mh-hannover.de
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DTSTART;TZID=Europe/Berlin:20260528T130000
DTEND;TZID=Europe/Berlin:20260528T140000
DTSTAMP:20260627T204821
CREATED:20260513T074502Z
LAST-MODIFIED:20260529T060333Z
UID:40963-1779973200-1779976800@www.resist-cluster.de
SUMMARY:ACME Seminar guest lecture by Prof. Dr. Christian Sieben
DESCRIPTION:Exciting topics\, interestingly presented: Every first and third Thursday (except during school holidays)\, RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series. \nAttend these exciting seminars of the Cluster of Excellence RESIST and the GRK ACME\, as a member of RESIST or as a colleague or student. \nOn Thursday\, 28. Mai 2026 at 13:00\, Prof. Dr. Christian Sieben\, HZI Braunschweig\, Research Group Nano Infektion Biology\, will give a talk with the title “Advanced imaging to decipher mechanistic details of zoonotic viral infections”. \nThe lecture will take place in Lecture Hall Q\, Building J6 of the Hannover Medical School. \nIf you are interested in participating online\, please contact RESIST@mh-hannover.de. \nDo you have any questions or suggestions about the RESIST seminar series? Then please contact us.
URL:https://www.resist-cluster.de/en/veranstaltung/acme-seminar-lecture-by-christian-sieben/
LOCATION:Hannover Medical School\, Building J6\, Lecture Hall Q\, Carl-Neuberg-Str. 1\, Hannover\, 30625
CATEGORIES:seminar (past)
ATTACH;FMTTYPE=image/png:https://www.resist-cluster.de/wp-content/uploads/2026/05/Ankuendigung-Seminar-Sieben_RESIST-HP.png
ORGANIZER;CN="RTG %E2%80%98Activation of Cellular anti-Microbial Effectors%E2%80%99 (ACME)":MAILTO:ACME.rtg3135@mh-hannover.de
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