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DTSTART;TZID=Europe/Berlin:20260429T130000
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DTSTAMP:20260424T120535
CREATED:20260416T050401Z
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UID:40424-1777467600-1777471200@www.resist-cluster.de
SUMMARY:ACME Seminar lecture by Prof. Antje Flieger
DESCRIPTION:Exciting topics\, interestingly presented: Every first and third Thursday (except during school holidays)\, RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series. \nAttend these exciting seminars of the Cluster of Excellence RESIST and the GRK ACME\, as a member of RESIST or as a colleague or student. \nOn WEDNESDAY\, 29 April 2026 at 13:00\, Prof. Antje Flieger\, Division of Bacterial Enteropathogens and Legionella\, Department of Infectious Diseases\, Robert Koch Institute\, Berlin\, will give a talk with the title “Legionella and Its Secreted Phospholipases: A Universe of Influence on Host and Pathogen”. \nAbout Professor Antje Flieger’s research\nLegionella are Gram-negative rod-shaped bacteria and the causative agents of Legionnaires’ disease\, a severe form of pneumonia that is fatal in approximately 9% of cases. According to a study by the Network for Community-Acquired Pneumonia (CAPNET)\, approximately 3.8% of all pneumonia cases in Germany are caused by Legionella\, which corresponds to approximately 20\,000 cases of Legionella infection per year. The goal of our research is to characterize virulence factors of Legionella. The focus here is on secreted phospholipases. At least 15 different phospholipases A\, some of which also exhibit lysophospholipase A and glycerophospholipid:cholesterol acyltransferase activity\, have been described to date for L. pneumophila. Analysis of the pathogen’s phospholipolytic activity is expected to provide a better understanding of the molecular processes involved in the modulation and destruction of lung cells during Legionnaires’ disease. This forms the basis for advancing the inhibition of cytolytic factors as a new therapeutic approach for improved treatment of patients with Legionnaires’ disease. \nThe lecture will take place in Lecture Hall H\, Building J01 of the Hannover Medical School. \nIf you are interested in participating online\, please contact RESIST@mh-hannover.de. \nDo you have any questions or suggestions about the RESIST seminar series? Then please contact us.
URL:https://www.resist-cluster.de/en/veranstaltung/acme-seminar-lecture-by-prof-antje-flieger/
LOCATION:MHH\, Hörsaal H\, Gebäude J01\, Carl-Neuberg-Str.1\, 30625 Hannover
CATEGORIES:seminar (upcoming)
ATTACH;FMTTYPE=image/jpeg:https://www.resist-cluster.de/wp-content/uploads/2026/02/Seminar_Vorschaubild_deu.jpg
ORGANIZER;CN="RTG %E2%80%98Activation of Cellular anti-Microbial Effectors%E2%80%99 (ACME)":MAILTO:ACME.rtg3135@mh-hannover.de
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DTSTART;TZID=Europe/Berlin:20260507T130000
DTEND;TZID=Europe/Berlin:20260507T140000
DTSTAMP:20260424T120535
CREATED:20260410T045757Z
LAST-MODIFIED:20260417T055636Z
UID:40345-1778158800-1778162400@www.resist-cluster.de
SUMMARY:RESIST Seminar guest lecture by Luis Schang\, MV\, PhD
DESCRIPTION:Exciting topics\, interestingly presented: Every Thursday\, RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series. \nAttend these exciting seminars of the Cluster of Excellence RESIST\, as a member of RESIST or as a colleague or student. \nOn 7 May 2026 at 1 p.m.\, Luis Schang\, MV\, PhD\, Professor of Chemical Virology\, Department of Microbiology & Immunology\, Baker Institute for Animal Health\, Cornell University\, will give a lecture with the title “HSV-1 and HSV-2 silencing during establishment of latency in human sensory neurons: implications for pathogenesis and therapy”. \nDespite the effective clinical antivirals approved since the 1980’s\, herpes simplex virus 1 and 2 (HSV-1\, -2) continue to pose major and chronic challenges to human health and well-being. Neonatal infections are life-threatening\, ocular infections are the most prevalent infectious cause of corneal transplants in the Western world\, herpes encephalitis is lethal or result in serious sequelae\, and genital herpes increases the risk of HIV infection\, among many other health problems. Herpes simplex viruses are also the cause of major mental health distress and may be involved in Alzheimer’s and other neurodegenerative diseases.\nThe ability of HSV-1 and 2 to establish life-long latent infections in sensory ganglia is the main barrier to effective management because latent virus does not express viral proteins\, which are the targets of most antivirals and vaccines. Latency is challenging to study\, too. We have developed a new model of latency in human sensory DRG and TG-like neurons and wild-type strains or clinical isolates of HSV-1 and -2. Latency is established with no antivirals\, antibodies\, cytokines\, or viral mutants and a low multiplicity\, reflecting the natural human infection. Using this model\, we will show that HSV-1 and -2 lytic genes are expressed during the acute neuronal infection\, viral genomes replicate and PML bodies are destroyed\, while the infection spreads for about 15-23 days before production of infectious virus ceases. Yet\, infected neurons survive\, PMLs reassemble around compacted genomes\, and the viral genomes persist indefinitely into latency. Viral genomes have positioned nucleosomes on day 7\, but nucleosome occupancy and positioning increased in latency. Four nucleosomes were positioned at and around an origin of DNA replication in latency but not during the acute infection. Reactivation up to 56 days after infection induces gene expression\, DNA replication and production of cell-free infectious virus with genomes replicated during the acute infection. Abortive reactivations may occur periodically in exceedingly rare neurons.\nTogether with the number of latent genomes per neuron in cadaveric human samples and latently infected mice\, and the activation of lytic promoters in mice before the establishment of latency\, these results challenge the conclusion that latency is established exclusively by unreplicated viral genomes with no previous lytic gene expression. These findings impact our understanding of the establishment of latency by herpes simplex viruses and the development of new antivirals acting on the critical stages of latency. \nThe lecture will take place in Lecture Hall Q\, Building J06 of the Hannover Medical School. \nIf you are interested in participating via video (online)\, please contact RESIST@mh-hannover.de. \nDo you have any questions or suggestions about the RESIST seminar series? Then please contact us.
URL:https://www.resist-cluster.de/en/veranstaltung/resist-seminar-guest-lecture-luis-schang/
LOCATION:Hannover Medical School\, Building J6\, Lecture Hall Q\, Carl-Neuberg-Str. 1\, Hannover\, 30625
CATEGORIES:seminar (upcoming)
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ORGANIZER;CN="RESIST Cluster of Excellence":MAILTO:RESIST@mh-hannover.de
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