Prof. Dr. Jochen Hühn participates in RESIST research projects A3 and B1.
| My Research Interest in RESIST |
Within RESIST we study the impact of microbiota during the neonatal period on the development, maturation and functional specialization of the gastrointestinal and systemic immune system, which is determining the individual’s immune status and susceptibility towards infectious diseases long- lastingly. Although it is widely accepted that microbiota are critically involved in this process, a detailed understanding of the involved microbial communities and microbiota-derived metabolites is still lacking.
Our research programme is based on our recent finding that early-life colonization by microbiota results in an epigenetic imprinting of unique functional properties within the gastrointestinal immune system and that neonatal infections can interfere with this process. Our long-term goal is to contribute to the development of therapeutic strategies based on early-life microbiome editing leading to a better development, maturation and functional specialization of the gastrointestinal and systemic immune system, thereby improving the health status of individuals long-lastingly.
Prof. Hühn about his scientific work
Prof. Dr. Jochen Hühn – Curriculum Vitae
Current Position
Since 2008 Full (W3) Professor of Experimental Immunology, MHH and Head of Department Experimental Immunology, HZI
Undergraduate and Postgraduate Training
1991 – 1996 Study of Biochemistry/Molecular Biology, University of Hamburg
1996 Diploma, Bernhard Nocht Institute for Tropical Medicine (BNI), Hamburg
1996 – 1999 Dissertation at BNI, Hamburg
1999 Dr. rer. nat. (PhD)
2000 Postdoctoral fellow at BNI, Hamburg
2000 – 2006 Postdoctoral fellow “Experimental Rheumatology”, Charité University Medicine, Berlin
Academic and Research Posts
2006 – 2008 Junior Professor for Immune Regulation, Charité University Medicine, Berlin
Since 2008 Full (W3) Professor of Experimental Immunology, MHH and Head of Department Experimental Immunology, HZI
Other Scientific Roles
Since 2007 Organizer of annual German Meeting on Immune Regulation
Since 2010 Board member, DFG Collaborative Research Centre 854
2011 – 2019 Board member, DFG Collaborative Research Centre 738
Since 2012 Organizer of annual European Midwinter Workshop on Immunology
Since 2013 Member of Editorial Board of “Immunity, Inflammation and Disease”
Since 2014 Advisory Board Member of the German Society of Immunology (DGfI)
2015 – 2019 Coordinator of EU-funded Innovative Training Network “ENLIGHT-TEN”
2017 Co-initiator of EFIS Study Group “T cell connect Europe”
2020 Coordinator of EU-funded Innovative Training Network “ENLIGHT-TEN+”
Awards and Prizes
2002 Avrion Mitchison Award for Rheumatism Research
2007 Wolfgang Schulze Award for Rheumatism Research
2007 Langener Science Award
10 Selected Publications
Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry GH, Vafadarnejad E, Floess S, Arampatzi P, Buettner M, Schweer J, Fleissner D, Vital M, Pieper DH, Basic M, Dersch P, Strowig T, Hornef M, Bleich A, Bode U, Pabst O, Bajenoff M, Saliba AE, Huehn J. Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat Commun. 2018; 9:3903
Pezoldt J*, Pisano F*, Heine W, Pasztoi M, Rosenheinrich M, Nuss AM, Pils MC, Prinz I, Förster R, Huehn J*, Dersch P*. CCR7 deficiency modulates T cell response and increases susceptibility to Yersinia pseudotuberculosis infection. J Infec Dis. 2017; 216:752-760. *equal contribution
Yang BH*, Hagemann S*, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J*, Lochner M*. Foxp3+ T cells expressing RORt represent a stable regulatory T cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2016; 9:444-457. *equal contribution
Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J. Imprinting of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res. 2015; 43:1537-1548.
Cording S*, Wahl B*, Kulkarni D, Chopra H, Pezoldt J, Buettner M, Dummer A, Hadis U, Heimesaat M, Bereswill S, Falk C, Bode U, Hamann A, Fleissner D, Huehn J*, and Pabst O*. The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol. 2014; 7:359-368. *equal contribution
Toker A, Engelbert D, Garg G, Polansky JK, Floess S, Miyao T, Baron U, Düber S, Geffers G, Giehr P, Schallenberg S, Kretschmer K, Olek S, Walter J, Weiss S, Hori S, Hamann A, Huehn J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol. 2013; 190:3180-3188.
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, and Hori S. Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 2012; 36:262-275.
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J*, Sparwasser T*. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007; 204:57-63. *equal contribution
Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein- Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007; 5:e38.
Huehn J*, Siegmund K*, Lehmann JC, Siewert C, Haubold U, Feuerer M, Debes GF, Lauber J, Frey O, Przybylski GK, Niesner U, de la Rosa M, Schmidt CA, Brauer R, Buer J, Scheffold A, Hamann A. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med. 2004; 199:303-313. *equal contribution
