|My Research Interest in RESIST|
We are interested in how the immune cells are shaped by environmental factors (e.g. microbiota, infections) during early childhood and how this can be linked to the susceptibility towards infections during life.
We have recently developed a high-throughput sequencing technology and applied bioinformatics methods to analyze human T cell receptor repertoires in relevant patient cohorts. Within RESIST we will take advantage of the PRIMAL cohort (coordinated by D. Viemann) to understand how a defined microbiota, but also infections may influence the postnatal maturation, individual responsiveness and antigen receptor repertoire of T cells and B cells in preterm babies. We further aim at identifying new biomarkers to predict the susceptibility of individual patients against infectious diseases, which may finally improve current therapeutic strategies.
Prof. Dr. Ravens about her scientific work
Prof. Dr. Sarina Ravens – Curriculum Vitae
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 17 original publications)
Tan L*, Sandrock I*, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Schmidt- Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav A, Krebs C, Prinz** I, Ravens S**. Single-cell transcriptomics identifies the adaptation of Scart1+ Vγ6+ T cells to skin residency as activated effector cells. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. equal contribution; **shared senior-authorship
DiLorenzo B, Ravens S*, Silva-Santos B*. High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire. Sci Data. 2019 Jul 4;6(1):115. **shared senior-authorship
DiLorenzo B, Simoes A, Caiado F, Tieppo P, Correia D, Carvalho T, Gomes da Silva M, Déchanet-Merville J, Schumacher T, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B. Broad cytotoxic targeting of acute myeloid leukemia by highly polyclonal Delta One T cells. Cancer Immunology Research 2019 Apr;7(4):552-558.
Ravens S*,# , Hengst J*, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H**, Prinz I**. Human gamma delta T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol. 2018 Mar 16;9:510. *,**equal contribution ; #corresponding author
Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C*, Prinz I*. Human gamma delta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017 Apr;18(4):393-401. *shared senior-authorship
Ravens S, Yu C, Ye T, Stierle M, Tora L. Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells. Epigenetics Chromatin. 2015 Nov 6;8:45.
Ravens S, Fournier M, Ye T, Stierle M, Dembele D, Chavant V, Tora L. Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation. Elife. 2014 Jun 4;3.
Reinhardt A, Ravens S, Fleige H, Haas JD, Oberdörfer L, Lyszkiewicz M, Förster R, Prinz I. CCR7-mediated migration in the thymus controls gamma delta T-cell development. Eur J Immunol. 2014 May;44(5):1320-9.
Haas JD*, Ravens S*, Düber S, Sandrock I, Oberdörfer L, Kashani E, Chennupati V, Föhse L, Naumann R, Weiss S, Krueger A, Förster R, Prinz I. Development of interleukin-17-producing gamma delta T cells is restricted to a functional embryonic wave. Immunity. 2012 Jul 27;37(1):48-59. *equal contribution
Giusti C, Luciani MF, Ravens S, Gillet A, Golstein P. Autophagic cell death in Dictyostelium requires the receptor histidine kinase DhkM. Mol Biol Cell. 2010 Jun 1;21(11):1825-35.