|My Research Interest in RESIST|
Varicella zoster virus (VZV) is a highly prevalent human pathogen that infects most human beings. During primary infection VZV causes chickenpox and establishes latency in neurons. Reactivation from neurons normally results in shingles. Most people control the infection but some individuals suffer from extreme chronic pain or life-threatening diseases.
Within RESIST we are interested in the identification and characterization of host and viral genetic determinants that are responsible for exacerbated VZV disease. A second focus of our research is the study of epigenetic modifications on the viral and human genomes during establishment of VZV latency. To do so we have established relevant viral and cellular models, including those to study VZV latency in human neurons derived from induced pluripotent stem cells. The patient cohorts and collaborations established within RESIST will ensure the achievement of the proposed aims.
Prof. Viejo-Borbolla about his scientific work
Prof. Dr. Abel Viejo-Borbolla – Curriculum Vitae
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 31 original publications)
Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner. Kropp KA, López-Muñoz AD, Ritter B, Martín R, Rastrojo A, Srivaratharajan S, Döhner K, Dhingra A, Czechowicz JS, Nagel CH, Sodeik B, Alcami A, Viejo-Borbolla A. J Virol. 2020 Sep 29;94(20):e01370-20. doi: 10.1128/JVI.01370-20. PMID: 32669337; PMCID: PMC7527038.
Baird NL, Zhu S, Pearce CM, Viejo-Borbolla A. Current in vitro models to study varicella zoster virus latency and reactivation. Viruses. 2019; 26: 11.
González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Rovis TL, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A. Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. PLoS Pathog. 2017; 13(5): e1006346.
Martinez-Martin N, Viejo-Borbolla A, Martín R, Blanco S, Benovic JL, Thelen M, Alcamí A. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun. 2015; 6: 6163.
Cabrera JR*, Viejo-Borbolla A*, Martinez-Martin N, Blanco S, Wandosell F, Alcami A. Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection. PLoS Pathog. 2015; 11(1): e1004571. *Both authors contributed equally.
Viejo-Borbolla A, Martinez-Martín N, Nel HJ, Rueda P, Martín R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcamí A. Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses. PLoS Pathog. 2012; 8(2): e1002497.
Viejo-Borbolla A, Martin AP, Muniz LR, Shang L, Marchesi F, Thirunarayanan N, Harpaz N, Garcia RA, Apostolaki M, Furtado GC, Mayer L, Kollias G, Alcami A, Lira SA. Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD. Mucosal Immunol. 2010; 3(6): 633-644.
Viejo-Borbolla A, Munoz A, Tabares E, Alcami A. Glycoprotein G from pseudorabies virus binds to chemokines with high affinity and inhibits their function. J Gen Virol. 2010; 91(Pt 1): 23-31.
Shang L, Thirunarayanan N, Viejo-Borbolla A, Martin AP, Bogunovic M, Marchesi F, Unkeless JC, Ho Y, Furtado GC, Alcami A, Merad M, Mayer L, Lira SA. Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine. Gastroenterology. 2009; 137(3): 1006-1018.
Viejo-Borbolla A, Ottinger M, Brüning E, Bürger A, König R, Kati E, Sheldon JA, Schulz TF. Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi’s Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol. 2005; 79(21): 13618-29.